Genetic Testing Interpretation with Opus 23

posted 5 Aug 2016, 04:09 by Tom Greenfield

Genetic testing for the public has been available from the American company 23andMe for some time, but interpretation of the raw data file with numbers and letters is a specialist task. The US FDA has limited the amount of health information that 23andMe can give to consumers, apart from ancestry data which can tell you who you else might be related to out of those who have done the test. Although used extensively for medical research, 23andMe allows users to find out whether their genes are more likely to give them curly hair, blue or green eyes and flush when they drink alcohol. 

Various independent interpretation services have been developed which analyse the 23andMe raw data and highlight important variations on the genes, or genetic mutations, but most of these reports still need an expert to understand the significance of the individual's mutations. Now a new tool for practitioners and researchers called Opus 23 can analyse the raw data in depth, and has many different reporting tools available depending on the area being researched. The software was written and programmed by naturopathic physician Dr Peter D'Adamo. The report features wording that the layperson can more easily understand, written in plain English. 

One useful feature of Opus 23 is that medical studies published on the US National Library of Medicine are extensively referenced for the effects of genetic mutations and for the effects of natural products on gene function. This can be used to devise a personalised prescription of natural medicines for the patient based on scientific research studies. Because these are based on the individual's own genetics, it is something that is more likely to work for them than simply taking a product because it helps others. 

One more thing that Opus 23 does is analyse the genetics of the gut microbiome using a uBiome test, and these results are integrated with the 23andMe test results for the individual to give even greater personalised recommendations.

Tom and Jacqueline Greenfield are editors and curators of the Opus 23 software, adding data and writing descriptions in technical scientific language for the practitioner and in plain English for the patient. They also run an online training course for practitioners wanting to use the software. They use Opus 23 extensively with their patients in their London and Canterbury clinics.

Professional Standards Association recommends CNHC therapists to Healthcare commissioners

posted 18 Mar 2015, 07:44 by Tom Greenfield

The Complementary and Natural Healthcare Council (CNHC) is a register accredited by the Professional Standards Authority, and registers Naturopaths in the UK, in addition to 16 other complementary therapies.

Complementary therapists on CNHC’s Accredited Register are included in the professions named by the Professional Standards Authority in its Accredited Registers Report to Ministers published today.

Harry Cayton, Chief Executive of the Professional Standards Authority said:

‘We all know we need to deliver new, innovative ways to improve people’s health. The NHS is re-examining the way it delivers services and is exploring new models of integrated care better-suited to today. That means looking beyond the traditional confines of our health and care system and the traditional health professions. The 63,000 practitioners on 17 Accredited Registers covering 25 occupations must be part of that, offering different approaches to care which commissioners can choose with the confidence that they are competent and safe.’

He continued:.....we no longer have to depend solely on doctors and nurses but can create broader multidisciplinary teams. We must invest in prevention and wellbeing to deliver healthcare for the 21st Century. The complementary therapists registered with CNHC are among the health practitioners who have a key role to play in this new model.”

CNHC’s Chair, John Lant commented:

‘We have over 5,000 practitioners on our Accredited Register from professions that are already used to support patients in areas such as cancer and palliative care and mental health services. The patient comments outlined in the report speak volumes about the role complementary therapies can play in enhancing patient wellbeing and we welcome wholeheartedly the Professional Standards Authority’s comments and report.” 

Naturopaths at Greenfields are members of the CNHC.

New: organic food intolerance test kit now available with a fingerprick sample

posted 26 Jul 2014, 05:47 by Tom Greenfield   [ updated 11 Jan 2017, 02:54 by Clinic Reception ]

Greenfields Clinic announce a test for IgG food intolerance which can now be done with a fingerprick sample instead of a venipuncture. The test is carried out at the specialist ProImmun lab in Germany, which uses only organic foods for testing. This avoids the potential cross-reactivity with pesticides, fungicides and herbicides that could happen with intolerance tests that use conventionally-farmed foods for testing. Using the food intolerance test in practice, our naturopaths have found the test highly sensitive and effective for patients with food intolerance in practice, as the test results for IgG (Immunoglobulins) 1-4 can also test for Candida Albicans yeast, as well as aspergillus niger, a mold that grows on some grains during storage. This can highlight a separate reason for intolerance to certain grains that would not otherwise show up in tests for the specific foods only. The ProImmun test results come with an optional food rotation plan with recipe book, and is the only intolerance test that can automatically remove from your food recommendations list the foods that contain aspergillus niger if you show an intolerance to it, or remove foods with known allergic reactions that may not also show up as intolerances, such as gluten (for people with coeliac disease) or dairy products (for people with lactose intolerance). The test also has the option to remove items from your food list which are high in histamine for people who have histamine-type symptoms such as headaches, rashes, itching, diarrhoea and abdominal pain, a different mechanism to IgG intolerance. These options can make the shopping list and rotation plan much more personalised to you.

This test was previously only available with a venipuncture blood sample, but now the fingerprick test kit allows patients to do the test at home with just six drops of blood and send the sample to the lab by post, also saving on the cost of the courier.

The ProImmun food intolerance test uses enzyme immuno-assay is available with the following number of foods tested: 
  • Pro-Immun Slim, 44 Antigens (recommended for children), includes milk, gluten, eggs and soya.
  • Pro-Immun, 91 Antigens includes as above, bananas, apples, lemons, garlic and some poultry.
  • Pro-Immun M, 181 Antigens (plus optional recipe book and food rotation plan), includes as above, pulses, grains and a range of fish.
  • Pro-Immun M-Plus, 270 Antigens (plus optional recipe book and food rotation plan), includes as above, tea, seafood, herbs, spices, a range of seasoning ingredients, selected E numbers and aspergillus niger.
Contact Greenfields Clinic reception on 01227 454 848 to order a food intolerance test.

N.B. IgG food intolerance testing looks for what is known as delayed hypersensitivity, it is not immediate hypersensitivity (IgE allergy), which includes hives, asthma, and potentially fatal, systemic allergic reactions (anaphylaxis) most often to peanuts, fish, seafood, or tree nuts; infants’ respiratory, skin, or digestive problems often due to ingestion of wheat, dairy, corn or soya in foods or  breast milkIgG food intolerance does not include adverse reactions from naturally occurring chemicals in foods, including salicylates, theobromine in chocolate, caffeine in coffee, solanines in nightshades, and tyramine in cheese. IgG intolerance does not cover reactions to food additives, including artificial colours, preservatives, flavours and sweeteners, monosodium glutamate (MSG), nitrites, and sulfites. IgG intolerance does not reveal the cause of symptoms resulting from impaired digestion, including deficient digestive enzymes or hydrochloric acid, lactose intolerance or malabsorption from a variety of digestive diseases (Crohn’s disease, coeliac disease, colitis, etc.). To investigate any of these may involve other testing, please contact our naturopaths for further information.

IgG testing should not be carried out if you have a raised temperature or have taken steroids or chemotherapy within the last four weeks, as the reactivity will not be as strong due to suppression of the immune system.

Vitamin D may help people with fibromyalgia

posted 1 Feb 2014, 15:11 by Tom Greenfield

A recent study found that vitamin D supplementation given to women diagnosed with fibromyalgia syndrome and who had low vitamin D levels, had significantly reduced pain when measured against placebo. The paper in Pain journal, "Effects of vitamin D on patients with fibromyalgia syndrome: A randomized placebo-controlled trial," studied thirty women diagnosed with fibromyalgia syndrome (FMS), with vitamin D levels below <32ng/mL (80nmol/L). They were either given vitamin D supplementation to bring their vitamin D levels to between 32 and 48ng/mL for 20weeks with oral vitamin D supplementation, or given a placebo. They were retested after a further 24 weeks without vitamin D supplementation. A marked reduction in pain according to the visual analogue scale was noted over the treatment period in the women who had taken the vitamin D. The authors conclude that optimisation of vitamin D levels in FMS had a positive effect on the perception of pain, and that this economical therapy few side effects may well be considered in patients with FMS. However, further studies with larger patient numbers are needed to prove the hypothesis.

Reference: 

Feel Good Oxyvenation at Greenfields

posted 29 Oct 2013, 03:49 by Tom Greenfield   [ updated 29 Oct 2013, 04:08 by Jacqueline Greenfield ]

Jacqueline Greenfield is now offering Oxyvenation sessions as adjunct to feeling good while you are being treated for your health problems. Call reception to book your appointment. Our clients say that they feel better longer when they combine Oxvenation with nutrition therapies such as Cell Symbiosis Therapy and the Blood Type and GenoType Diets.

Report on the IfHI UK Conference 14-15th September 2013

posted 29 Oct 2013, 03:39 by Jacqueline Greenfield   [ updated 29 Oct 2013, 04:04 ]

On September 14-15 2013 Dr. Peter D’Adamo ND was special guest and keynote speaker at the IfHI UK Conference and Inaugural Launch of the International College of Generative Medicine. It was the first time Dr. D’Adamo had spoken at an IfHI Conference outside the United States, and he drew an international crowd of delegates from Eire, Northern Ireland, Scotland, France, Germany, Switzerland, Poland, Chile and the US.

The conference started on the Saturday at greenfields clinic, Canterbury, with a special workshop for the fifteen people taking the IfHI Fellow or Master certification training. Taught by Tom and Jacqueline Greenfield, delegates were shown a live demonstration of a SWAMI Pro GenoType assessment with a volunteer patient from greenfields clinic. Real-time observation of the interviewing, taking measurements, data input and assessment process data from a real patient generated relevant questions and interaction among the group.

Students then practiced their skills of ABO typing and taking blood samples for Lewis blood tests, and worked on each other in pairs using the NAP GenoTyping Kit. Lewis test samples were later tested in greenfields laboratory, and secretor status results were mailed out to the students.

A webinar each for IfHI Master and Fellow students the week prior to the conference had helped them to assimilate the information in their study guides, and the test papers were issued at the conference. Students submitted a high standard of work with their multiple choice papers and essay questions, which were sent to IfHI Head Office in the US for grading.

On the Sunday, 26 delegates including existing IfHI Fellows and Masters met in The Veg Box Café, Canterbury, for the main conference. Included in their delegate packs was an electronic version of Generative Medicine Volume I: Systems, Concepts and Pathways, on a USB flash drive, a generous gift from Dr. D’Adamo of his 800-page textbook used as the reference guide for the didactic education modules of the new Center of Excellence in Generative Medicine Studies at the University of Bridgeport. The textbook also contains all the research used as the basis for Dr. D’Adamo’s popular book The GenoType Diet: Change your Genetic Destiny.

Jacqueline Greenfield ND Lic Ac. MIfHI opened the event on Sunday with a presentation introducing the future structure of IfHI. She revealed to delegates that this conference marked the beginning of the transition from IfHI to the International College of Generative Medicine (ICGM). A new curriculum would allow for the creation of a trainer or coach of personalised nutrition concepts to assist members of the public wanting to include aspects of personalised nutrition in their lives, and to help them set and reach personal goals to maintain their wellbeing. 

In addition, delegates saw that their platform to train enabling them to teach and help the public will be enhanced. Dr. Greenfield assured existing and new IfHI Fellow and Master certificate holders that they would be eligible for a fast track into training for the new title. 

A new tiered structure of membership was introduced for the ICGM, with criteria for entry and allowing practitioners to be able to study and certify at the same level of education as naturopathic physicians in the US. There was an open discussion about the future of IfHI, and delegates became inspired by the high standards of education at the ICGM, which would in turn improve the value of their certification. At future ICGM conferences lay people will be able to audit the events to enhance their continuing education in addition to practitioners who are certifying. Naturopathic physicians outside the US will be assisted in a path to achieving ICGM certification, which will help to raise the standards of naturopathic medicine worldwide.

Jacqueline Greenfield explained to delegates that their attendance of the IfHI Conference entitles them to one year’s membership of IfHI, and that previous IfHI members whose membership has lapsed, a renewal membership fee would be required for them to participate in the transition to the ICGM or the personalised nutrition certification. All members will be required to complete ICGM approved continuing education credits to maintain membership and/or certification. These CEUs will be identified soon.

Tom Greenfield ND DO MIfHI then presented on “The science behind the GenoType Diet biometrics.” Combining knowledge of genetic linkage from the blood groups with the epigenetic factors associated with biometric measurements, the SWAMI GenoType software gives both practitioners and lay people a chance to further refine their dietary and lifestyle approach to maintaining and improving their health. New research, such as a 2013 study into D2:D4 ratio showing those with longer fourth fingers and therefore higher testosterone levels are less likely to trust others, further strengthens the concept of genetic archetypes proposed by Dr. D’Adamo in his book The GenoType Diet: Change Your Genetic Destiny. Other new research published last year confirms the association with environmental stress on the pregnant mother causing changes in limb length on the offspring, as seen in the SWAMI GenoType measurements. 

A lunch suitable for all blood types was served to conference delegates as old friends met and new friendships were forged. Amongst the delegates were Drs. Stuart Semple and Karl Reitmann, long-time MIfHI graduates. 

After lunch Dr. Peter D’Adamo ND MIfHI gave his keynote presentation on the main concepts of Generative Medicine, entitled: “Epigenetics and phenotypic plasticity: Methods of assessment and actionable consequences.” Dr. D’Adamo introduced some topics in the Generative Paradigm, including network medicine, fragility, Generative Strategies, protein folding, lectins, hormesis, heat shock stress response, amongst other topics. Using the four ‘P’s of systems biology, Predict, Prevent, Personalise and Participate, Dr. D’Adamo gave examples of how Generative Medicine is put into practice at the University of Bridgeport Center of Excellence, including his unique software platform “Quodlibet”. This online computer programme allows the user to investigate the natural agents that interact with specific biochemical pathways, and create personalised prescriptions in real time. The presentation was well received by the audience, most of whom had been studying for their Fellow or Master certification. 

After the event, North American Pharmacal invited all delegates to an informal reception with drinks and canapés at the local Abode hotel. The Lord Mayor of Canterbury attended the event to greet Dr. D’Adamo, and invited him and his wife Martha to a personal guided tour of the City on their next visit. Delegates had a chance to mingle with Dr. D’Adamo and Martha, and group photographs were taken of all attendees.

Successful IfHI Conference in Canterbury

posted 17 Sep 2013, 11:08 by Tom Greenfield   [ updated 23 Sep 2013, 10:13 ]

The IfHI Conference with special guest Dr. Peter D'Adamo was held at The Veg Box Café in Canterbury, delegates heralded the conference a great success. The reception after the event was attended by the Lord Mayor of Canterbury and the Lady Mayoress at the Abode Hotel.
IfHI UK Conference Group Photograph
Photo copyright Paul Hopfensperger FIfHI, Body and Mind Studio Limited, UK and reproduced with permission

UK IfHI Conference Deadline Extended

posted 4 Sep 2013, 15:01 by Tom Greenfield   [ updated 4 Sep 2013, 15:03 ]

The final deadline for registration for the IfHI Conference featuring Dr. Peter D'Adamo has been extended to Friday 6th September, book now! All delegates at the conference will receive a free copy of Dr. D'Adamo's Fundamentals of Generative Medicine textbook, worth £200.

Details of Dr. Peter D'Adamo's Presentation at the UK Regional IfHI Conference

posted 3 Jul 2013, 07:44 by Tom Greenfield   [ updated 3 Jul 2013, 07:46 ]

Dr. Peter D'Adamo ND, MIfHI, will be presenting the following seminar at the IfHI Regional Conference on Sunday 15th September 2013
Epigenetics and phenotypic plasticity: Methods of assessment and actionable consequences.

ABSTRACT: Post-genomic (epigenetic) influences on gene expression are well-recognized factors behind the flux and mutability that characterizes the development of inter-individual differences. However the critical role of the glycome (the complement of glycans of an organism) in the modulation of phenotypic plasticity is far less known. Glycosylation acts as an important 'finishing school,’ imbuing high-value information on to proteins and lipids that controls and regulates cell functions as diverse as morphogenesis, heat shock responses, apoptosis, hormesis, metastasis and phenotypic canalization. Because the glycome is downstream from the genome, its assessment is surprisingly phenotypic in nature. This is especially beneficial to the busy clinician as many interesting and helpful conclusions can be draw in real-time, via surprisingly simple and cost-effective methods.

GOALS:

To foster greater understanding of how the glycome influences the wider dynamics of inter-individuality and introduce the functional concept of an 'epiglycome'.

To move the nutrigenomic discussion beyond current genome/SNP/haplotype deterministic model, which despite major improvements in throughput, are prohibitively expensive and only marginally predictive.

LEARNING OBJECTIVES:

  1. Understand the basics of glycobiology and how this applies to the clinical assessment of the patient
  2. Understand the appropriate analytic methodologies (serologic, biometric and dermatoglyphic) that underpin the assessment of the glycome
  3. Learn appropriate lifestyle suggestions and therapeutic interventions based upon conclusions drawn from 1 and 2

IfHI UK Regional Conference and Certification

posted 1 Jun 2013, 05:23 by Tom Greenfield

Announcing a UK conference with Keynote speaker Dr. Peter D'Adamo ND: 
Tom and Jacqueline Greenfield are holding an Institute for Human Individuality Regional Conference in Canterbury on 15th September. Early booking is recommended. 
For further information see the booking page.

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